Protein Name
Rab11 family-interacting protein 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
58279
Protein Length
512
Protein Domain
3D Structure
(PDB ID : 2gzd)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Recycling endosome membrane;
Function
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Gene Ontology
GO:0030659; GO:0005768; GO:0043231; GO:0005654; GO:0005886; GO:0055038; GO:0042802; GO:0042803; GO:0019901; GO:0017137; GO:0030010; GO:0035773; GO:1903078; GO:0045055; GO:0003091