TICRR | Treslin
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
TICRR
Synonyms
C15orf42
Protein Name
Treslin
UniProt ID
Q7Z2Z1 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000268138
NCBI Gene ID
90381
Molecular Weight
210857
Protein Length
1910
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Gene Ontology
GO:0005654; GO:0005634; GO:0003682; GO:0006281; GO:0006260; GO:0001731; GO:0007093; GO:0033314; GO:0030174; GO:0010212