Protein Name
Neuroepithelial cell-transforming gene 1 protein
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
67740
Protein Length
596
Protein Domain
3D Structure
(PDB ID : 3eo2)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus;
Function
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Gene Ontology
GO:0005829; GO:0005634; GO:0005085; GO:0005089; GO:0070301; GO:0071479; GO:0007186; GO:0035556; GO:0051451; GO:0043065; GO:0043547; GO:0001558; GO:0035023; GO:0051056; GO:0007165