CaMKinet | Result

Gene

TLK2

Synonyms

Protein Name

Serine/threonine-protein kinase tousled-like 2

UniProt ID

Q86UE8 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000316512

NCBI Gene ID

11011

Molecular Weight

87661

Protein Length

772

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 5o0y)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Nucleus,Cytoplasm,Perinuclear region,Cytoplasm,Cytoskeleton;

Function

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Gene Ontology

GO:0005882; GO:0005634; GO:0048471; GO:0005524; GO:0004674; GO:0007049; GO:0006974; GO:0071480; GO:0006325; GO:0007059; GO:0035556; GO:0010507; GO:0032435; GO:0018105; GO:0006468; GO:0001672