CaMKinet | Result

Gene

RIMS1

Synonyms

KIAA0340 RAB3IP2 RIM1

Protein Name

Regulating synaptic membrane exocytosis protein 1

UniProt ID

Q86UR5 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000264839

NCBI Gene ID

22999

Molecular Weight

189073

Protein Length

1692

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2css)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell membrane,Cell junction,Synapse,Cell junction,Synapse,Presynaptic cell membrane;

Function

Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Ontology

GO:0030054; GO:0048788; GO:0005829; GO:0005886; GO:0048786; GO:0098831; GO:0042734; GO:0045202; GO:0030695; GO:0044325; GO:0046872; GO:0017137; GO:0003723; GO:0017156; GO:0048791; GO:0006886; GO:0061025; GO:1903861; GO:2000463; GO:0010628; GO:0097151; GO:0050806; GO:0065003; GO:0045055; GO:0042391; GO:0046928; GO:0048167; GO:2000300; GO:0050896; GO:0046903; GO:0016079; GO:0007601