ZC3HC1 | Nuclear-interacting partner of ALK
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
ZC3HC1
Synonyms
NIPA
Protein Name
Nuclear-interacting partner of ALK
UniProt ID
Q86WB0 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000309301
NCBI Gene ID
51530
Molecular Weight
55262
Protein Length
502
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Gene Ontology
GO:0031965; GO:0005634; GO:0019901; GO:0008270; GO:0007049; GO:0051301; GO:2001240; GO:0016567