Protein Name
Patatin-like phospholipase domain-containing protein 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
53657
Protein Length
486
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
Localization
Lipid droplet,Cell membrane;
Function
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
Gene Ontology
GO:0005737; GO:0005829; GO:0016021; GO:0005811; GO:0016020; GO:0005654; GO:0005886; GO:0004806; GO:0044242; GO:0034389; GO:0055088; GO:0019915; GO:0010891; GO:0010898; GO:0019433