KSR1 | Kinase suppressor of Ras 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
KSR1
Synonyms
KSR
Protein Name
Kinase suppressor of Ras 1
UniProt ID
Q8IVT5 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000381958
NCBI Gene ID
8844
Molecular Weight
102160
Protein Length
923
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5vyk)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Membrane,Cell membrane,Cell projection,Ruffle membrane,Endoplasmic reticulum membrane;
Function
Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.
Gene Ontology
GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0032991; GO:0032587; GO:0071889; GO:0005524; GO:0051087; GO:0051879; GO:0005078; GO:0046872; GO:0031434; GO:0008022; GO:0004672; GO:0019933; GO:0000165; GO:0043410; GO:0007265; GO:0042127; GO:0043405
 
Gene Ontology