TPH2 | Tryptophan 5-hydroxylase 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
TPH2
Synonyms
NTPH
Protein Name
Tryptophan 5-hydroxylase 2
UniProt ID
Q8IWU9 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000329093
NCBI Gene ID
121278
Molecular Weight
56057
Protein Length
490
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 4v06)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
1.14.16.4; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan
Localization
Function
-
Gene Ontology
GO:0005829; GO:0043005; GO:0005506; GO:0004510; GO:0009072; GO:0071285; GO:0007623; GO:0014823; GO:0051592; GO:0043627; GO:0051384; GO:0031667; GO:0042427