Protein Name
Protein KIBRA
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
125301
Protein Length
1113
Protein Domain
3D Structure
(PDB ID : 2z0u)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytoplasm,Perinuclear region,Nucleus,Cell projection,Ruffle membrane;
Function
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.
Gene Ontology
GO:0005737; GO:0005829; GO:0005634; GO:0048471; GO:0032991; GO:0032587; GO:0019900; GO:0032947; GO:0003713; GO:0016477; GO:0030010; GO:0035329; GO:0035331; GO:0046621; GO:0000122; GO:0043410; GO:0007221; GO:0035330; GO:0032386