Mrtfa | Myocardin-related transcription factor A
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
Mrtfa
Synonyms
Bsac Mal Mkl1
Protein Name
Myocardin-related transcription factor A
UniProt ID
Q8K4J6 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000105207
NCBI Gene ID
223701
Molecular Weight
102546
Protein Length
964
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2v51)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Nucleus;
Function
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381).
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0003779; GO:0003785; GO:0003700; GO:0043522; GO:0003713; GO:0000976; GO:0030036; GO:0030900; GO:2001234; GO:0043154; GO:0001764; GO:0031175; GO:0045944; GO:0010735; GO:0045893; GO:0006357; GO:0051145
 
Gene Ontology