Gene
Synonyms
B55 MAP4K6 MINK YSK2 ZC3
Protein Name
Misshapen-like kinase 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
149822
Protein Length
1332
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell projection,Axon,Cell projection,Dendrite;Isoform 4: Golgi apparatus;
Function
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Gene Ontology
GO:0030424; GO:0030054; GO:0005737; GO:0005829; GO:0030425; GO:0070062; GO:0005794; GO:0014069; GO:0045211; GO:0005524; GO:0004672; GO:0004674; GO:0031532; GO:0032147; GO:0007268; GO:0048813; GO:0007254; GO:0000165; GO:0007275; GO:0048812; GO:0046330; GO:1900745; GO:0046777; GO:0006468; GO:2000311; GO:0030334; GO:0022407; GO:0001952; GO:0023014; GO:0031098