TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
TAB3
Synonyms
MAP3K7IP3
Protein Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt ID
Q8N5C8 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000368212
NCBI Gene ID
257397
Molecular Weight
78653
Protein Length
712
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Function
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Gene Ontology
GO:0005829; GO:0010008; GO:0070062; GO:0005886; GO:0046872; GO:0000187; GO:0038095; GO:0007249; GO:0070498; GO:0007254; GO:0002755; GO:0010507; GO:0070423; GO:0043123; GO:0051092; GO:0002223