Protein Name
Serine/threonine-protein kinase Nek11
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
74192
Protein Length
645
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Nucleus,Nucleus,Nucleolus;
Function
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Gene Ontology
GO:0005730; GO:0005654; GO:0005524; GO:0046872; GO:0004674; GO:0016572; GO:0031573; GO:0035556; GO:0044772; GO:0006468; GO:1901990