STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein][tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)

Cytoplasm,Nucleus,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cell junction,Synapse;

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

GO:0030054; GO:0005813; GO:0005737; GO:0150034; GO:0005654; GO:0005634; GO:0048786; GO:0008021; GO:0005524; GO:0043015; GO:0000287; GO:0019901; GO:0004674; GO:0048156; GO:0050321; GO:0008306; GO:0007409; GO:0006974; GO:0051298; GO:0030010; GO:0035556; GO:0090176; GO:0007095; GO:0030182; GO:0007269; GO:0006468; GO:0050770; GO:0010975; GO:0048167; GO:2000807; GO:0009411; GO:0099504