Protein Name
Partitioning defective 3 homolog
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
151423
Protein Length
1356
Protein Domain
3D Structure
(PDB ID : 2kom)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Endomembrane system,Cell junction,Cell junction,Tight junction,Cell junction,Adherens junction,Cell membrane,Cytoplasm,Cell cortex,Cytoplasm,Cytoskeleton;
Function
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).
Gene Ontology
GO:0005912; GO:0043296; GO:0016324; GO:0044295; GO:0005923; GO:0005938; GO:0030054; GO:0005913; GO:0005911; GO:0005737; GO:0005856; GO:0005829; GO:0012505; GO:0033269; GO:0043025; GO:0005886; GO:0032991; GO:0042802; GO:0035091; GO:0005547; GO:0032266; GO:0005546; GO:0019903; GO:0008356; GO:0007409; GO:0070830; GO:0007155; GO:0007049; GO:0030010; GO:0051660; GO:0090162; GO:0007163; GO:0045197; GO:0000226; GO:0022011; GO:0010801; GO:0031643; GO:0007205; GO:0008104; GO:0006612; GO:0065003; GO:0060341; GO:0007179