Gene
Synonyms
KIAA1298 SSH1L
Protein Name
Protein phosphatase Slingshot homolog 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
115511
Protein Length
1049
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphateH2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphateH2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
Localization
Cytoplasm,Cytoskeleton,Cell projection,Lamellipodium,Cleavage furrow,Midbody;
Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Gene Ontology
GO:0032154; GO:0005737; GO:0005856; GO:0005829; GO:0030426; GO:0030027; GO:0030496; GO:0005886; GO:0003779; GO:0004721; GO:0004725; GO:0008138; GO:0030036; GO:0000902; GO:0071318; GO:0098976; GO:1904719; GO:2000463; GO:1901216; GO:0031915; GO:1904754; GO:0006470; GO:0008064; GO:0050770; GO:0032268; GO:0010591