Protein Name
Titin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
3816030
Protein Length
34350
Protein Domain
3D Structure
(PDB ID : 1tki)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Gene Ontology
GO:0000794; GO:0005829; GO:0070062; GO:0005576; GO:0031674; GO:0031430; GO:0030017; GO:0005865; GO:0030018; GO:0051015; GO:0042805; GO:0005524; GO:0005509; GO:0005516; GO:0019899; GO:0042802; GO:0051371; GO:0002020; GO:0019901; GO:0043621; GO:0004674; GO:0004713; GO:0008307; GO:0097493; GO:0031433; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0035995; GO:0007076; GO:0006936; GO:0030049; GO:0002576; GO:0010628; GO:0050714; GO:0010737; GO:0050790; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0006941; GO:0071688