Crtc3 | CREB-regulated transcription coactivator 3
 
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Sequence Viewer
Gene
Crtc3
Synonyms
Torc3
Protein Name
CREB-regulated transcription coactivator 3
UniProt ID
Q91X84 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000113540
NCBI Gene ID
70461
Molecular Weight
67027
Protein Length
619
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Cytoplasm;
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0008140; GO:0097009; GO:0042116; GO:0043951; GO:0050995; GO:0032793; GO:0045944; GO:0051289