Gene
Synonyms
Smt3ip2 Supr1
Protein Name
Sentrin-specific protease 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
67579
Protein Length
588
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Localization
Isoform 1: Nucleus,Nuclear pore complex,Nucleus membrane;Isoform 2: Cytoplasm,Cytoplasmic vesicle;Isoform 3: Nucleus,PML body;
Function
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Isoform 3 activates transcription.
Gene Ontology
GO:0005737; GO:0031410; GO:0005829; GO:0016604; GO:0031965; GO:0005643; GO:0005634; GO:0016605; GO:0019904; GO:0070139; GO:0070140; GO:0009950; GO:0045444; GO:0007507; GO:0060711; GO:0051028; GO:0035562; GO:0043518; GO:0032091; GO:0031397; GO:1901797; GO:0001934; GO:0031398; GO:0045944; GO:0031648; GO:0016926; GO:0015031; GO:0032875; GO:2000045; GO:0051246; GO:0060712; GO:0060707; GO:0016055