SEPT8 | Septin-8
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
SEPT8
Synonyms
KIAA0202
Protein Name
Septin-8
UniProt ID
Q92599 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000296873
NCBI Gene ID
23176
Molecular Weight
55756
Protein Length
483
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Cytoplasm,Cytoskeleton,Cell junction,Synapse,Cell projection,Axon,Cytoplasmic vesicle,Secretory vesicle,Synaptic vesicle membrane;
Function
Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.
Gene Ontology
GO:0030424; GO:0030054; GO:0015630; GO:0098793; GO:0031105; GO:0005940; GO:0030672; GO:0005525; GO:0003924; GO:0032947; GO:0061640; GO:0033157; GO:0031647; GO:0035542
 
Gene Ontology