Med1 | Mediator of RNA polymerase II transcription subunit 1
 
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Sequence Viewer
Gene
Med1
Synonyms
Crsp210 Drip205 Pbp Pparbp Trap220 Trip2
Protein Name
Mediator of RNA polymerase II transcription subunit 1
UniProt ID
Q925J9-4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000018304
NCBI Gene ID
19014
Molecular Weight
167141
Protein Length
1575
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1xdk)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (By similarity).
Gene Ontology
GO:0000785; GO:0016592; GO:0005730; GO:0005654; GO:0005634; GO:0032993; GO:0000151; GO:0003682; GO:0031490; GO:0003677; GO:0030331; GO:0050693; GO:0036033; GO:0035257; GO:0016922; GO:0030374; GO:0042975; GO:0044877; GO:0042974; GO:0000979; GO:0000978; GO:0038023; GO:0046966; GO:0030375; GO:0003713; GO:0003712; GO:0003714; GO:0008134; GO:0061630; GO:0042809; GO:0006702; GO:0030521; GO:0001525; GO:0009887; GO:0031100; GO:0007420; GO:0043010; GO:0000902; GO:0071364; GO:0035729; GO:0071383; GO:0097067; GO:0035050; GO:0035162; GO:0035116; GO:0001892; GO:0048822; GO:0060750; GO:0070371; GO:0048821; GO:0045444; GO:0007507; GO:0001701; GO:0030518; GO:0030216; GO:0007595; GO:0002088; GO:0001889; GO:0060745; GO:0060744; GO:0033598; GO:0035855; GO:0030224; GO:0042789; GO:0007275; GO:0043066; GO:0010839; GO:0045665; GO:0000122; GO:0035357; GO:0008284; GO:0045648; GO:0070318; GO:0010628; GO:2000347; GO:0060335; GO:0033148; GO:0045618; GO:0033601; GO:2000273; GO:0045944; GO:0045893; GO:0016567; GO:2001141; GO:0006356; GO:0006355; GO:0070562; GO:0003406; GO:0006590; GO:0002154; GO:0006366; GO:0006367; GO:0003222
 
Gene Ontology