Gene
Synonyms
ESTRB NR3A2
Protein Name
Estrogen receptor beta
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
59216
Protein Length
530
Protein Domain
3D Structure
(PDB ID : 1l2j)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Gene Ontology
GO:0005576; GO:0005739; GO:0005654; GO:0005634; GO:0003677; GO:0003700; GO:0000981; GO:0019899; GO:0030284; GO:0034056; GO:0042802; GO:0004879; GO:0048019; GO:0000978; GO:0005496; GO:0003707; GO:0003713; GO:0008270; GO:0007267; GO:0071392; GO:0030520; GO:0030308; GO:0000122; GO:0051091; GO:0045944; GO:0045893; GO:0006355; GO:0007165; GO:0006367