Protein Name
CREB-binding protein
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
265351
Protein Length
2442
Protein Domain
3D Structure
(PDB ID : 1jsp)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493).
Gene Ontology
GO:0005737; GO:0000123; GO:0016604; GO:0000790; GO:0005654; GO:0005634; GO:0016407; GO:0003682; GO:0003684; GO:0004402; GO:0043426; GO:0002039; GO:0034212; GO:0000987; GO:0001102; GO:0001085; GO:0003713; GO:0003714; GO:0008134; GO:0008270; GO:1904837; GO:0034644; GO:0042733; GO:0016573; GO:0042592; GO:0018076; GO:0000122; GO:0007219; GO:0045747; GO:0045944; GO:0007221; GO:0045893; GO:0030511; GO:0032481; GO:0006473; GO:0031648; GO:0065003; GO:0042981; GO:1900034; GO:0019216; GO:0045637; GO:0008589; GO:0061418; GO:0006355; GO:0001666; GO:0048511; GO:0007165; GO:0002223; GO:0006367; GO:0016032