MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MAP4K1
Synonyms
HPK1
Protein Name
Mitogen-activated protein kinase kinase kinase kinase 1
UniProt ID
Q92918 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000380066
NCBI Gene ID
11184
Molecular Weight
91296
Protein Length
833
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 6cqd)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Function
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Gene Ontology
GO:0005737; GO:0005622; GO:0016020; GO:0005524; GO:0008349; GO:0004672; GO:0004674; GO:0007257; GO:0000185; GO:0032147; GO:0008283; GO:1904628; GO:0018105; GO:0046777; GO:0006468; GO:0023014; GO:0031098
 
Gene Ontology