PPP1R14A | Protein phosphatase 1 regulatory subunit 14A
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PPP1R14A
Synonyms
CPI17 PPP1INL
Protein Name
Protein phosphatase 1 regulatory subunit 14A
UniProt ID
Q96A00 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000301242
NCBI Gene ID
94274
Molecular Weight
16693
Protein Length
147
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm;
Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Gene Ontology
GO:0005829; GO:0004865; GO:0035690; GO:0042325