MARK4 | MAP/microtubule affinity-regulating kinase 4
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MARK4
Synonyms
KIAA1860 MARKL1
Protein Name
MAP/microtubule affinity-regulating kinase 4
UniProt ID
Q96L34 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000262891
NCBI Gene ID
57787
Molecular Weight
82520
Protein Length
752
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5es1)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoskeleton,Microtubule organizing center,Cytoplasm,Cytoskeleton,Cilium basal body,Cytoplasm,Cytoskeleton,Cilium axoneme,Cytoplasm,Cell projection,Dendrite;
Function
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).
Gene Ontology
GO:0005813; GO:0036064; GO:0005737; GO:0005829; GO:0030425; GO:0000930; GO:0015630; GO:0005815; GO:0030496; GO:0043005; GO:0005524; GO:0043015; GO:0008017; GO:0004674; GO:0048156; GO:0050321; GO:0043130; GO:0007049; GO:0051301; GO:0097711; GO:0044782; GO:0030010; GO:0035556; GO:0001578; GO:0000226; GO:0007399; GO:0045724; GO:0043068; GO:1904781; GO:0006468; GO:0046605
 
Gene Ontology