NOX5 | NADPH oxidase 5
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
NOX5
Synonyms
-
Protein Name
NADPH oxidase 5
UniProt ID
Q96PH1-4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000454143
NCBI Gene ID
79400
Molecular Weight
86439
Protein Length
765
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
1.6.3.-; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Membrane;Isoform v2: Endoplasmic reticulum;Isoform v5: Endoplasmic reticulum;
Function
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.
Gene Ontology
GO:0005783; GO:0005789; GO:0043020; GO:0005886; GO:0005509; GO:0050660; GO:0020037; GO:0050661; GO:0015252; GO:0016175; GO:0001525; GO:0006915; GO:0008283; GO:0034599; GO:0050663; GO:0061640; GO:0006952; GO:0001935; GO:0055114; GO:2000379; GO:0043012; GO:0010155; GO:0042554
 
Gene Ontology