STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Nucleus,Nucleus,Nucleolus,Cytoplasm;

Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

GO:0005737; GO:0016592; GO:0016607; GO:0005730; GO:0005654; GO:0005634; GO:1990904; GO:0005667; GO:0030374; GO:0030674; GO:0003723; GO:0003712; GO:0002218; GO:0098534; GO:0006310; GO:0006281; GO:0006260; GO:0042921; GO:0016575; GO:0045087; GO:0030520; GO:0046600; GO:0045944; GO:0009725; GO:0060395