CaMKinet | Result

Gene

RCHY1

Synonyms

ARNIP CHIMP PIRH2 RNF199 ZNF363

Protein Name

RING finger and CHY zinc finger domain-containing protein 1

UniProt ID

Q96PM5 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000321239

NCBI Gene ID

25898

Molecular Weight

30110

Protein Length

261

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2jrj)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.3.2.27; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Localization

Nucleus,Nucleus speckle,Cytoplasm;

Function

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Gene Ontology

GO:0005737; GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0000151; GO:0002039; GO:0042803; GO:0005102; GO:0004842; GO:0008270; GO:0070987; GO:0032436; GO:0031398; GO:0051865; GO:0016567; GO:0006511