CaMKinet | Result

Gene

DLC1

Synonyms

ARHGAP7 KIAA1723 STARD12

Protein Name

Rho GTPase-activating protein 7

UniProt ID

Q96QB1 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000276297

NCBI Gene ID

10395

Molecular Weight

170591

Protein Length

1528

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2dky)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Cell junction,Focal adhesion,Membrane;

Function

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Gene Ontology

GO:0005901; GO:0030864; GO:0005737; GO:0005829; GO:0005925; GO:0005634; GO:0032587; GO:0005096; GO:0008289; GO:0042169; GO:0030036; GO:0006919; GO:0006915; GO:0048041; GO:0030900; GO:0003007; GO:0021575; GO:0030336; GO:0008285; GO:0051895; GO:0035024; GO:0051497; GO:0001843; GO:1900119; GO:0035307; GO:0032956; GO:0008360; GO:0051056; GO:0007165