Gene
Synonyms
RAP80 RXRIP110
Protein Name
BRCA1-A complex subunit RAP80
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
79727
Protein Length
719
Protein Domain
3D Structure
(PDB ID : 2mkf)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Gene Ontology
GO:0070531; GO:0016604; GO:0005654; GO:0005634; GO:0042393; GO:0070530; GO:0006302; GO:0006303; GO:0070537; GO:0045892; GO:0045739; GO:0016579; GO:0010212; GO:0072425