Protein Name
Paired amphipathic helix protein Sin3a
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
145175
Protein Length
1273
Protein Domain
3D Structure
(PDB ID : 1po4)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus,Nucleus,Nucleolus;
Function
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).
Gene Ontology
GO:0000785; GO:0000776; GO:0005730; GO:0005654; GO:0005634; GO:0016580; GO:0005667; GO:0017053; GO:0003682; GO:0003700; GO:0033558; GO:0044877; GO:0003723; GO:0001102; GO:0001103; GO:0003714; GO:0000976; GO:0002218; GO:0007568; GO:0034613; GO:1903351; GO:0071333; GO:0006260; GO:0002244; GO:0016575; GO:0001701; GO:0043066; GO:0042754; GO:1901675; GO:1900181; GO:0000122; GO:2000678; GO:0045892; GO:0031937; GO:0002230; GO:0010971; GO:0045944; GO:0006476; GO:0010817; GO:0019216; GO:0045652; GO:0043619; GO:0051595; GO:0048511