CaMKinet | Result

Gene

PHB2

Synonyms

BAP REA

Protein Name

Prohibitin-2

UniProt ID

Q99623 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000412856

NCBI Gene ID

11331

Molecular Weight

33296

Protein Length

299

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Mitochondrion inner membrane,Cytoplasm,Nucleus;

Function

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Gene Ontology

GO:0030424; GO:0071944; GO:0009986; GO:0005737; GO:0098982; GO:0098978; GO:0005743; GO:0005741; GO:0005739; GO:0016363; GO:0005634; GO:0014069; GO:0048786; GO:0032991; GO:0033218; GO:0030331; GO:0008022; GO:0047485; GO:0071456; GO:0071300; GO:0060749; GO:0060744; GO:0006851; GO:0007005; GO:0043066; GO:0043433; GO:0033147; GO:0033600; GO:0045892; GO:1902808; GO:0051091; GO:0070374; GO:0031536; GO:0006606; GO:0050821; GO:0060762; GO:0009611; GO:0007062