MAP3K5 | Mitogen-activated protein kinase kinase kinase 5
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
Synonyms
ASK1 MAPKKK5 MEKK5
Protein Name
Mitogen-activated protein kinase kinase kinase 5
UniProt ID
Q99683 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
154537
Protein Length
1374
Protein Domain
3D Structure
(PDB ID : 5uox)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
2.7.11.25; (BRENDA)
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Endoplasmic reticulum;
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Gene Ontology
GO:0005829; GO:0009897; GO:1990604; GO:1902911; GO:0032991; GO:0005524; GO:0042802; GO:0000287; GO:0004709; GO:0019904; GO:0042803; GO:0004672; GO:0019901; GO:0019903; GO:0004674; GO:0007257; GO:0000186; GO:0097190; GO:0034198; GO:0070301; GO:1902170; GO:0071356; GO:0072577; GO:0045087; GO:0070059; GO:0008631; GO:0007254; GO:0000165; GO:0038066; GO:0043065; GO:0010666; GO:0043280; GO:0046330; GO:0043507; GO:0045663; GO:1901216; GO:1900745; GO:0045893; GO:1904707; GO:0097300; GO:0006468; GO:0034976; GO:0002931; GO:0051403; GO:0016032; GO:0042060
 
Gene Ontology