Protein Name
Neuroligin-1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
94149
Protein Length
843
Protein Domain
3D Structure
(PDB ID : 3b3q)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell junction,Synapse,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density;
Function
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671).
Gene Ontology
GO:0030054; GO:0009986; GO:0030425; GO:0043198; GO:0043197; GO:0060076; GO:0009897; GO:0032433; GO:0098978; GO:0005794; GO:0005887; GO:0099060; GO:0017146; GO:0005886; GO:0014069; GO:0098793; GO:0045202; GO:0050839; GO:0042043; GO:0030165; GO:0046983; GO:0097110; GO:0038023; GO:0097113; GO:0016339; GO:0071277; GO:0048789; GO:0045184; GO:1904861; GO:0007157; GO:0060291; GO:0050804; GO:0061002; GO:0007399; GO:0097115; GO:0007158; GO:0140058; GO:0031175; GO:0097114; GO:0010841; GO:0060999; GO:2000463; GO:0051491; GO:1902533; GO:1905520; GO:1902474; GO:1900029; GO:0051965; GO:0032230; GO:0051968; GO:2000809; GO:1900244; GO:2000302; GO:0097119; GO:0097104; GO:0098698; GO:0097105; GO:0051290; GO:0051260; GO:0035418; GO:0006605; GO:0097120; GO:2000311; GO:0045664; GO:2000310; GO:0099174; GO:0002087; GO:0098942; GO:0048511; GO:0007416; GO:0050808; GO:0099560; GO:0097091; GO:0048488; GO:0016080; GO:0048489; GO:0072553