TINF2 | TERF1-interacting nuclear factor 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
TINF2
Synonyms
TIN2
Protein Name
TERF1-interacting nuclear factor 2
UniProt ID
Q9BSI4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000267415
NCBI Gene ID
26277
Molecular Weight
50023
Protein Length
451
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 3bqo)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Chromosome,Telomere;Isoform 1: Nucleus matrix;
Function
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Gene Ontology
GO:0000781; GO:0016604; GO:0000784; GO:0016363; GO:0000783; GO:0005654; GO:0010370; GO:0070187; GO:0042162; GO:0050680; GO:0010836; GO:0032211; GO:0070198; GO:1904356; GO:0032202; GO:0016233