MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MKNK1
Synonyms
MNK1
Protein Name
MAP kinase-interacting serine/threonine-protein kinase 1
UniProt ID
Q9BUB5-2 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000361013
NCBI Gene ID
8569
Molecular Weight
51342
Protein Length
465
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2hw6)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Isoform 2: Cytoplasm;Isoform 3: Cytoplasm,Nucleus;
Function
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0046872; GO:0004674; GO:0035556; GO:0018105; GO:0046777; GO:0006468; GO:0006417
 
Gene Ontology