CaMKinet | Result

Gene

CARD11

Synonyms

CARMA1

Protein Name

Caspase recruitment domain-containing protein 11

UniProt ID

Q9BXL7 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000380150

NCBI Gene ID

84433

Molecular Weight

133284

Protein Length

1154

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 4jup)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Membrane raft;

Function

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.

Gene Ontology

GO:0032449; GO:0005737; GO:0005829; GO:0070062; GO:0001772; GO:0045121; GO:0005886; GO:0050700; GO:0004385; GO:0030183; GO:0042100; GO:0038095; GO:0048872; GO:0007249; GO:0002377; GO:0070970; GO:0030890; GO:0001819; GO:0043123; GO:0045086; GO:0051092; GO:0042102; GO:0042981; GO:0045577; GO:0045580; GO:0002223; GO:0031295; GO:0050852; GO:0045061; GO:0038202