PINK1 | Serine/threonine-protein kinase PINK1, mitochondrial
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PINK1
Synonyms
-
Protein Name
Serine/threonine-protein kinase PINK1, mitochondrial
UniProt ID
Q9BXM7 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000364204
NCBI Gene ID
65018
Molecular Weight
62769
Protein Length
581
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Mitochondrion outer membrane,Mitochondrion inner membrane,Cytoplasm,Cytosol;
Function
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).
Gene Ontology
GO:0097449; GO:0030424; GO:0044297; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0030426; GO:0031307; GO:0097413; GO:0016020; GO:0005743; GO:0005758; GO:0005741; GO:0005739; GO:0005634; GO:0048471; GO:0005524; GO:0055131; GO:0010857; GO:0016301; GO:0000287; GO:0016504; GO:0002020; GO:0004672; GO:0043422; GO:0004674; GO:0031625; GO:0032148; GO:0000422; GO:1904881; GO:0071456; GO:0034599; GO:0097237; GO:0072655; GO:0035556; GO:0016236; GO:0072656; GO:0007005; GO:0099074; GO:1902902; GO:1903147; GO:0010629; GO:1903384; GO:1903298; GO:2001243; GO:1903751; GO:0046329; GO:0016242; GO:0090258; GO:0043524; GO:1903202; GO:1903204; GO:2000378; GO:0036289; GO:0018105; GO:2001171; GO:1903852; GO:0051091; GO:0033603; GO:1904544; GO:1901727; GO:0043123; GO:0016239; GO:1902958; GO:0090141; GO:0098779; GO:1904783; GO:0010952; GO:0033138; GO:0035307; GO:0051897; GO:0001934; GO:1903955; GO:0031398; GO:0090200; GO:0032226; GO:0045727; GO:0051443; GO:0006468; GO:0050821; GO:0016567; GO:1903146; GO:1900407; GO:0010310; GO:0051881; GO:0010821; GO:0002082; GO:0061136; GO:0043254; GO:1903214; GO:0031396; GO:2000377; GO:1902803; GO:0022904; GO:0002931; GO:0006979; GO:0038203; GO:0006511
 
Gene Ontology