POLDIP3 | Polymerase delta-interacting protein 3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
POLDIP3
Synonyms
KIAA1649 PDIP46
Protein Name
Polymerase delta-interacting protein 3
UniProt ID
Q9BY77 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000252115
NCBI Gene ID
84271
Molecular Weight
46089
Protein Length
421
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Nucleus speckle,Cytoplasm;
Function
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.
Gene Ontology
GO:0005737; GO:0036464; GO:0005829; GO:0016607; GO:0005654; GO:0044877; GO:0003723; GO:0031124; GO:0006406; GO:0016973; GO:0045727; GO:0006405