Protein Name
Sarcolipin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
3808
Protein Length
31
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Sarcoplasmic reticulum membrane,Endoplasmic reticulum membrane;
Function
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:21697544, PubMed:26816378). Required for muscle-based, non-shivering thermogenesis (PubMed:22961106).
Gene Ontology
GO:0016021; GO:0016529; GO:0033017; GO:0030234; GO:0120162; GO:0051924; GO:1901894; GO:1901077; GO:0070296