SIK2 | Serine/threonine-protein kinase SIK2
 
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Sequence Viewer
Gene
SIK2
Synonyms
KIAA0781 QIK SNF1LK2
Protein Name
Serine/threonine-protein kinase SIK2
UniProt ID
Q9H0K1 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000305976
NCBI Gene ID
23235
Molecular Weight
103915
Protein Length
926
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm;
Function
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Gene Ontology
GO:0005737; GO:0031588; GO:0005634; GO:0005524; GO:0000287; GO:0004674; GO:0042149; GO:0035556; GO:0032007; GO:0046777; GO:0006468; GO:0046626
 
Gene Ontology