Protein Name
Thioredoxin-interacting protein
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
43661
Protein Length
391
Protein Domain
3D Structure
(PDB ID : 4gei)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Gene Ontology
GO:0005737; GO:0005829; GO:0005758; GO:0005634; GO:0004857; GO:0031625; GO:0007049; GO:0071228; GO:0030216; GO:0051782; GO:0000122; GO:0048008; GO:0043065; GO:0006606; GO:0042127; GO:0051592; GO:0032355; GO:0009749; GO:0042542; GO:0009612; GO:0032570