RANBP3 | Ran-binding protein 3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
RANBP3
Synonyms
-
Protein Name
Ran-binding protein 3
UniProt ID
Q9H6Z4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000034275
NCBI Gene ID
8498
Molecular Weight
60210
Protein Length
567
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2crf)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Nucleus;
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Gene Ontology
GO:0005737; GO:0005643; GO:0005654; GO:0005634; GO:0070412; GO:0008536; GO:0043547; GO:0006611