Protein Name
Claspin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
151094
Protein Length
1339
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Gene Ontology
GO:0005794; GO:0005654; GO:0010997; GO:0003677; GO:0032147; GO:0000077; GO:0006281; GO:0006260; GO:0033314; GO:0007095; GO:0018105; GO:0016579