Protein Name
Ubiquitin-conjugating enzyme E2 J1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
34990
Protein Length
318
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
Localization
Endoplasmic reticulum membrane;
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
Gene Ontology
GO:0005789; GO:0016021; GO:0005524; GO:0061631; GO:0031625; GO:1904153; GO:0018279; GO:0042534; GO:0007286; GO:0030433