GCM1 | Chorion-specific transcription factor GCMa
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
GCM1
Synonyms
GCMA
Protein Name
Chorion-specific transcription factor GCMa
UniProt ID
Q9NP62 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000259803
NCBI Gene ID
8521
Molecular Weight
49268
Protein Length
436
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).
Gene Ontology
GO:0005634; GO:0005667; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042826; GO:0000978; GO:0008134; GO:0008270; GO:0009653; GO:0060018; GO:0060670; GO:0060706; GO:0060143; GO:0045944; GO:0060800; GO:0006355; GO:0006366