PNPLA8 | Calcium-independent phospholipase A2-gamma
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PNPLA8
Synonyms
IPLA22 IPLA2G
Protein Name
Calcium-independent phospholipase A2-gamma
UniProt ID
Q9NP80 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000257694
NCBI Gene ID
50640
Molecular Weight
88477
Protein Length
782
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.1.5; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine
Localization
Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasm,Perinuclear region;
Function
Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
Gene Ontology
GO:0005789; GO:0000139; GO:0016021; GO:0005622; GO:0016020; GO:0048471; GO:0005778; GO:0005777; GO:0005524; GO:0047499; GO:0004622; GO:0004623; GO:0019369; GO:0050482; GO:0008219; GO:0006631; GO:0043651; GO:0036151; GO:0034638; GO:0036152; GO:0046338; GO:0001516
 
Gene Ontology