BAZ1A | Bromodomain adjacent to zinc finger domain protein 1A
 
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Sequence Viewer
Gene
Synonyms
ACF1 WCRF180
Protein Name
Bromodomain adjacent to zinc finger domain protein 1A
UniProt ID
Q9NRL2 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
178702
Protein Length
1556
Protein Domain
3D Structure
(PDB ID : 5uiy)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Catalytic Activity
-
Localization
Nucleus;
Function
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.
Gene Ontology
GO:0016590; GO:0008623; GO:0046872; GO:0006338; GO:0006261; GO:0016573; GO:0006357